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Alcohol-triggered signs of migraine: An animal model
Yaqoub Alabwah1, Yadong Ji1, David A Seminowicz2,3
1a Department of Endodontics, Prosthodontics and Operative Dentistry , University of Maryland School of Dentistry , Baltimore , MD , USA ;
Abstract:
We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.
