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Updated: Mar 23, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

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Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Ko Sakatsume1, Masatoshi Akiyama2, Kenki Saito3

  • 1Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, 980-8574, Japan. kosakatsume@gmail.com.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|March 30, 2016
PubMed

A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.

Keywords:
Acquired von Willebrand syndromeBleeding tendencyVentricular assist deviceVon Willebrand factors

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