Related Experiment Video
Updated: Mar 23, 2026
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Celiac Disease and Risk of Autoimmune Disorders: A Population-Based Matched Birth Cohort Study
Cristina Canova1, Gisella Pitter1, Jonas F Ludvigsson2
1Laboratory of Public Health and Population Studies, Department of Molecular Medicine, University of Padua, Padua, Italy.
Insights
Children with celiac disease (CD) face a higher risk of developing autoimmune hypothyroidism and type 1 diabetes mellitus (T1DM). Early surveillance is recommended for timely detection of these autoimmune comorbidities.
Area of Science:
- Pediatric Endocrinology
- Autoimmune Diseases
- Gastroenterology
Background:
- Celiac disease (CD) is an autoimmune disorder.
- Children with CD may have an increased risk of other autoimmune conditions.
- Type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease are common comorbidities.
Purpose of the Study:
- To evaluate the relative risk of developing T1DM and autoimmune thyroid disease in children diagnosed with CD.
- To identify potential associations between CD and subsequent autoimmune conditions.
Main Methods:
- A matched cohort study design utilizing administrative data.
- Inclusion of 1215 CD cases and 6075 matched controls.
- Cox regression models to estimate hazard ratios for autoimmune diseases.
Main Results:
- Individuals with CD showed a significantly increased risk of hypothyroidism (HR 4.64).
- A trend towards increased risk for T1DM was observed (HR 2.50), though not statistically significant.
- Hypothyroidism risk was notably higher in males compared to females.
Conclusions:
- Children and adolescents with CD are at a heightened risk for autoimmune hypothyroidism and T1DM.
- Routine screening and surveillance for these comorbidities in pediatric CD patients are warranted.
- Timely detection can improve management and outcomes for associated autoimmune conditions.
Objectives:
To estimate the relative risk of developing type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease in children with celiac disease (CD).
Study Design:
A matched cohort design with linkage of administrative data was adopted. A total of 1215 cases of CD and 6075 references matched by sex and year of birth born in Friuli Venezia Giulia Region (Italy) between 1989 and 2011 were included. Cox regression models were used to estimate hazard ratios (HRs) for autoimmune diseases in patients with CD compared with references, stratified by sex and age at diagnosis.
Results:
Individuals with CD had an increased risk of subsequent hypothyroidism (HR 4.64 [95% CI 2.88-7.46]) and T1DM (HR 2.50 [95% CI 0.94-6.66]), the latter not statistically significant. Risk of hypothyroidism was higher in males (HR 20.00; 95% CI 5.64-70.87) than females (HR 3.21; 95% CI 1.85-5.57) (P value <.01). No differences were observed between males and females risks for diabetes or age at CD diagnosis. The small number of hyperthyroidism cases identified precluded any statistical analysis.
Conclusions:
Children and youth with CD are at increased risk of developing autoimmune hypothyroidism and to some extent T1DM. This suggests the need for surveillance of children with CD in order to timely detect the onset of such comorbidities.
More Related Videos
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Related Concept Videos
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Other Disorders of Digestive System
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...