Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.9K
Drugs Acting on Autonomic Ganglia: Blockers01:28

Drugs Acting on Autonomic Ganglia: Blockers

1.8K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.8K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

117.4K
Overview
117.4K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

8.2K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
8.2K
Autonomic Nervous System01:22

Autonomic Nervous System

15.0K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
15.0K
Equilibrium and Balance01:15

Equilibrium and Balance

7.8K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute migraine treatments in patients above age 65.

Headache·2026
Same author

Potential role of tirzepatide, a dual GLP-1 and GIP receptor agonist, for preventive treatment of migraine: A case series.

Headache·2026
Same author

Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.

Headache·2026
Same author

Long-Term Reductions in Headache Frequency, Severity, and Disability with Eptinezumab in Adults with Chronic Migraine: Results from the PREVAIL Trial.

Pain and therapy·2026
Same author

Focus on migraine prodrome: what should clinicians know?

Current opinion in neurology·2026
Same author

Safety, tolerability, and efficacy of atogepant added to onabotulinumtoxinA for the preventive treatment of chronic migraine: A phase 3, multicenter, 24-week, open-label study.

Cephalalgia : an international journal of headache·2026

Related Experiment Video

Updated: Mar 23, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K

A Practical Approach to Autonomic Dysfunction in Patients with Headache.

Jessica Ailani1

  • 1Georgetown Headache Center, Department of Neurology, Medstar Georgetown University Hospital, 3800 Reservoir Road NW, 7PHC, Washington, DC, 20007, USA. Jessica.x.ailani@gunet.georgetown.edu.

Current Neurology and Neuroscience Reports
|March 30, 2016
PubMed
Summary

Autonomic symptoms complicate headache diagnosis. Understanding the link between the trigeminal system, hypothalamus, and autonomic dysfunction aids in diagnosing headaches like migraine and trigeminal autonomic cephalalgias.

Keywords:
Autonomic dysfunctionCluster headacheMigraineTrigeminal autonomic cephalalgia

More Related Videos

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.7K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.1K

Related Experiment Videos

Last Updated: Mar 23, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K
Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.7K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.1K

Area of Science:

  • Neurology
  • Neuroscience
  • Autonomic Nervous System Research

Background:

  • Autonomic symptoms frequently complicate headache diagnosis.
  • These symptoms are characteristic of trigeminal autonomic cephalalgias but also occur in migraine and secondary headaches.
  • The interplay between the trigeminal system and hypothalamus underlies cranial autonomic symptoms in headache disorders.

Purpose of the Study:

  • To review the pathophysiology of autonomic dysfunction in headache.
  • To examine the prevalence of autonomic symptoms across various headache types.
  • To present diagnostic techniques for headaches involving autonomic dysfunction.

Main Methods:

  • Literature review focusing on the pathophysiology of cranial autonomic symptoms.
  • Analysis of studies reporting autonomic dysfunction in primary and secondary headaches.
  • Synthesis of diagnostic strategies for headache patients with autonomic features.

Main Results:

  • Autonomic dysfunction is a key feature in several headache disorders, not limited to trigeminal autonomic cephalalgias.
  • The trigeminal-hypothalamic pathway is central to the generation of cranial autonomic symptoms.
  • Diagnostic challenges arise from the varied presentation of autonomic symptoms.

Conclusions:

  • Recognizing autonomic symptoms is crucial for accurate headache diagnosis.
  • Understanding the trigeminal-hypothalamic axis provides insight into headache pathophysiology.
  • Implementing specific diagnostic techniques can improve patient outcomes for headaches with autonomic features.