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Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons
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On the move, lysosomal CAX drives Ca2+ transport and motility
1School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK Lloyd-EvansE@cardiff.ac.uk.
The Journal of Cell Biology
|March 30, 2016
Abstract:
Acidic Ca(2+)stores are important sources of Ca(2+)during cell signaling but little is known about how Ca(2+)enters these stores. In this issue, Melchionda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510019) identify a Ca(2+)/H(+)exchanger (CAX) that is required for Ca(2+)uptake and cell migration in vertebrates.
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