Post thrombolytic resolution of ST elevation in STEMI patients

Area of Science:

• Cardiology
• Emergency Medicine
• Clinical Research

Background:

• ST-elevation myocardial infarction (STEMI) requires prompt treatment.
• Thrombolytic therapy is a cornerstone in STEMI management.
• Optimizing treatment timing and understanding influencing factors are crucial for patient outcomes.

Purpose of the Study:

• To investigate the impact of thrombolytic therapy timing on ST-segment resolution in STEMI patients.
• To assess the influence of cardiac risk factors (diabetes, hypertension, hyperlipidemia) and infarction site on thrombolysis efficacy.
• To correlate electrocardiographic (ECG) findings with treatment parameters.

Main Methods:

• A descriptive, hospital-based study involving 83 STEMI patients.
• Data collected on time from chest pain onset to thrombolysis administration (Streptokinase).
• ECG monitoring for ST-segment resolution post-thrombolysis; statistical analysis using chi-square test.

Main Results:

• Thrombolysis within 12 hours of chest pain onset showed significantly higher complete ST-segment resolution (72.88%) compared to after 12 hours (0%).
• Diabetes and hypertension were associated with poorer ST-resolution post-thrombolysis.
• Hyperlipidemia and infarction site did not demonstrate a statistically significant effect on ST-resolution.

Conclusions:

• Early thrombolytic therapy (within 12 hours) is critical for effective ST-segment resolution in STEMI.
• Diabetic and hypertensive patients exhibit reduced response to thrombolysis.
• Infarction site and hyperlipidemia do not significantly alter thrombolysis effectiveness in STEMI patients.