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Updated: Mar 23, 2026
Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells
Published on: June 28, 2013
Human-induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases
Anita M Chanana1, June-Wha Rhee, Joseph C Wu
1aStanford Cardiovascular Institute bDepartment of Medicine, Division of Cardiology cDepartment of Radiology dInstitute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
Purpose Of Review:
The article provides an overview of advances in the induced pluripotent stem cell field to model cardiomyopathies of inherited inborn errors of metabolism and acquired metabolic syndromes in vitro.
Recent Findings:
Several inborn errors of metabolism have been studied using 'disease in a dish' models, including Pompe disease, Danon disease, Fabry disease, and Barth syndrome. Disease phenotypes of complex metabolic syndromes, such as diabetes mellitus and aldehyde dehydrogenase 2 deficiency, have also been observed.
Summary:
Differentiation of patient and disease-specific induced pluripotent stem cell-derived cardiomyocytes has provided the capacity to model deleterious cardiometabolic diseases to understand molecular mechanisms, perform drug screens, and identify novel drug targets.
