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Transoral incisionless fundoplication: current status.

Karim Sami Trad¹

¹Department of Surgery, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Current Opinion in Gastroenterology

|March 30, 2016

Summary

Transoral incisionless fundoplication (TIF) offers a durable solution for chronic GERD. This endoscopic procedure effectively manages symptoms and heals esophagitis, providing an alternative when medications fail.

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Efficacy of transoral fundoplication for treatment of chronic gastroesophageal reflux disease incompletely controlled with high-dose proton-pump inhibitors therapy: a randomized, multicenter, open label, crossover study.

BMC gastroenterology·2014

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Area of Science:

Gastroenterology
Minimally Invasive Surgery

Background:

Chronic gastroesophageal reflux disease (GERD) affects a significant patient population.
Current treatments include medical therapy and surgical interventions.
Transoral incisionless fundoplication (TIF) with the EsophyX device is an endoscopic option.

Purpose of the Study:

To reevaluate the efficacy and safety of TIF.
To assess its role in managing chronic GERD.
To review recent randomized controlled trials and long-term data.

Main Methods:

Review of randomized controlled trials (RCTs) and long-term follow-up data.
Analysis of TIF's impact on GERD symptoms, esophagitis, and acid exposure.
Evaluation of safety profile, including adverse events and patient-reported outcomes.

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Main Results:

RCTs confirm TIF's ability to resolve GERD symptoms and heal esophagitis.
TIF demonstrates superiority over conventional medical therapy in selected patients.
Long-term data show sustained efficacy up to 6 years with a low adverse event rate.

Conclusions:

TIF is a valuable endoscopic treatment for moderate to severe chronic GERD.
It offers a safe and effective alternative, particularly when proton-pump inhibitors are insufficient.
Appropriate patient selection is key for successful TIF outcomes.