Related Experiment Video
Updated: Sep 26, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 28, 2007
[Clinical characteristics of progressive supranuclear paralysis (the Steele-Richardson-Olszewski syndrome)]
Abstract:
We analyzed the clinical features and therapeutic response of 6 patients with progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome). The mean duration from the onset to establishing the diagnosis was 2.7 years, with the initial false diagnosis of Parkinson's disease in 4 patients. The most common symptoms at the moment of diagnosing were unsteady gait, speech difficulties, forgetfulness and rigidity, in addition to impairment of vertical gaze. In all the patients therapeutical response was inadequate. Clinical criteria for differential diagnosis of progressive supranuclear palsy are discussed.
Related Concept Videos
Parkinson's Disease: Overview
Multiple Sclerosis l: Introduction
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology
Myasthenia Gravis ll: Pathophysiology
Alterations in Muscle Tone lll

