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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum
Quírico A Castillo, Jorge Triana1, José L Eiroa1
1Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria , Campus de Tafira, 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.
Abstract:
Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM.
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