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Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
Published on: August 17, 2017
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Opioids increase hip fracture risk: a meta-analysis
Fumin Ping1, Ying Wang2, Jing Wang3
1Department of Operating Room, Affiliated Hospital of Hebei University of Engineering, Handan, China.
Journal of Bone and Mineral Metabolism
|March 30, 2016
Summary
Opioid use significantly increases hip fracture risk. This meta-analysis of 10 studies found a 54% higher risk for opioid users, confirming a link between these medications and bone fractures.
Area of Science:
- Gerontology
- Pharmacology
- Orthopedics
Background:
- The association between opioid use and hip fracture risk is not well-established.
- Existing studies present conflicting evidence, necessitating a comprehensive review.
Purpose of the Study:
- To conduct a meta-analysis assessing the risk of hip fracture in patients using opioid medications.
- To quantify the overall risk and explore heterogeneity in the relationship between opioid use and hip fractures.
Main Methods:
- A systematic literature search was conducted on PubMed and EMBASE databases up to June 2015.
- Data from ten eligible studies involving 697,011 patients were pooled using a random-effects model.
- Heterogeneity and publication bias were assessed through subgroup and sensitivity analyses.
Main Results:
- The pooled relative risk for hip fracture among opioid users was 1.54 (95% CI 1.34-1.77).
- Subgroup analyses identified sources of heterogeneity, and sensitivity analyses confirmed the robustness of the findings.
- No significant publication bias was detected.
Conclusions:
- Opioid use is significantly associated with an increased risk of hip fracture.
- These findings highlight the importance of considering fracture risk in patients prescribed opioids.
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