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Updated: Mar 23, 2026
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Prognostic value of funisitis and/or chorionic vasculitis compared to histologic chorioamnionitis in full-term
Hongyan Du1,2, Enqi Liu1, Changfu Xu1
1a Department of Pathology , School of Medicine, Xi'an Jiaotong University , Xi'an , China.
Aim:
To compare pathological findings in the placenta and cord with the prognosis of full-term infants in cases of neonatal infection and microbial analyses.
Methods:
The pathological findings in the placenta and cord and microbial analyses of amniotic fluid and neonatal samples based on culture or polymerase chain reaction (PCR) were observed in 1208 full-term mother-infant pairs at our center. We also collected neonatal clinical infection data, such as the occurrence of septicemia and other infectious diseases.
Results:
Neonatal infection and positive identification of microorganisms were more common in the funisitis and/or chorionic vasculitis group than in the histologic chorioamnionitis group.
Conclusion:
Funisitis and/or chorionic vasculitis is a valuable pathological marker for assessing the comparison between intrauterine infection and neonatal inflammatory conditions in infants delivered at full-term.
Insights
Histologic examination of the placenta and umbilical cord, specifically funisitis and/or chorionic vasculitis, can help predict neonatal infections in full-term infants. These findings are more indicative of infection than histologic chorioamnionitis alone.
Area of Science:
- Perinatal Medicine
- Pathology
- Neonatology
Background:
- Intrauterine infections pose risks to term infants.
- Accurate diagnosis of neonatal infection is crucial for prognosis.
Purpose of the Study:
- To correlate placental and umbilical cord pathology with neonatal infection outcomes.
- To evaluate microbial analyses in identifying intrauterine infections.
- To compare diagnostic value of different placental inflammatory markers.
Main Methods:
- Studied 1208 full-term mother-infant pairs.
- Examined placental and umbilical cord pathology.
- Performed microbial analyses (culture, PCR) on amniotic fluid and neonatal samples.
- Collected data on neonatal infections like septicemia.
Main Results:
- Funisitis and/or chorionic vasculitis were more frequently associated with neonatal infection and microbial identification.
- Histologic chorioamnionitis showed a lower association with positive microbial findings.
Conclusions:
- Funisitis and/or chorionic vasculitis are significant pathological markers for intrauterine infection.
- These markers aid in assessing neonatal inflammatory conditions in term infants.
- Pathological findings provide valuable insights into infection risk and prognosis.
