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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Candida albicans shunt infection

S Shapiro1, T Javed, J Mealey

  • 1Department of Neurosurgery, Indiana University Medical Center, Indianapolis.

Pediatric Neuroscience
|January 1, 1989
PubMed

Insights

Successfully treating Candida albicans shunt infections requires shunt removal and Amphotericin B. Key risk factors include serious illness and prematurity, with infection occurring during placement or via bloodstream spread.

Area of Science:

  • Infectious Diseases
  • Neurosurgery
  • Mycology

Background:

  • Cerebrospinal fluid (CSF) shunt infections pose significant challenges, particularly those caused by fungal pathogens like Candida albicans.
  • Early and effective treatment is crucial to prevent severe neurological complications.

Observation:

  • This report details seven successful cases of Candida albicans CSF shunt infections.
  • Treatment involved shunt removal combined with intravenous Amphotericin B, and in four cases, intraventricular Amphotericin B was also administered.

Findings:

  • Major risk factors identified include serious underlying medical conditions, recent antibiotic use, indwelling catheters (intravascular or Foley), concurrent candidiasis, and premature birth with low birth weight.
  • Candida shunt infections can arise from contamination during shunt surgery or through hematogenous spread from a distant infection site.

Implications:

  • These findings highlight the importance of recognizing risk factors for Candida shunt infections in vulnerable patient populations.
  • The reported treatment regimen provides a successful model for managing these challenging infections.
  • Understanding the routes of infection (contamination vs. hematogenous) can inform preventative strategies in neurosurgical procedures.

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