Related Experiment Video
Updated: Mar 23, 2026

05:17
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
2.1K
In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
Mostafa M Ghorab1,2, Mansour S Alsaid3, Mohammed S Al-Dosari4
1Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. mmsghorab@yahoo.com.
Molecules (Basel, Switzerland)
|March 30, 2016
Abstract:
A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.

