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Updated: Mar 23, 2026

Zebrafish Model of Neuroblastoma Metastasis

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Published on: March 14, 2021

Mayo Clinic Zebrafish Facility Overview.

Ryan E Leveque¹, Karl J Clark¹, Stephen C Ekker¹

¹Biochemistry and Molecular Biology, Mayo Clinic , Rochester, Minnesota.

|March 30, 2016

Summary

This summary is machine-generated.

The zebrafish (Danio rerio) is a valuable vertebrate model organism for human health research. Its biological similarity, genetic tools, and the Mayo Clinic Zebrafish Facility (MCZF) support diverse scientific investigations.

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Immunostaining of Dissected Zebrafish Embryonic Heart

Immunostaining of Dissected Zebrafish Embryonic Heart

Published on: January 10, 2012

Area of Science:

* Comparative biology and genetics
* Model organism research

Background:

* Zebrafish (Danio rerio) are a widely used nonmammalian vertebrate model organism.
* Biological similarity to humans, advanced molecular genetics, and available tools drive their utility.
* The Mayo Clinic Zebrafish Facility (MCZF) supports global research efforts.

Purpose of the Study:

* To describe the infrastructure and resources of the Mayo Clinic Zebrafish Facility (MCZF).
* To highlight the simplified larval fish rearing protocol using Paramecia.
* To emphasize the MCZF's role in supporting diverse research and training new scientists.

Main Methods:

* Housing approximately 2,000 tanks with an Internet cloud-based bar-coding system.
* Utilizing zfishbook.org web infrastructure for annotation.
* Implementing a simplified Paramecia-based culture protocol for larval fish.

Main Results:

* The MCZF provides a robust system for housing and managing zebrafish.
* A simplified protocol for larval fish rearing using Paramecia is detailed.
* The facility supports ongoing research and serves as a training hub.

Conclusions:

* The zebrafish is a powerful model organism for understanding development, disease, and health.
* The MCZF offers essential resources and infrastructure for zebrafish research.
* The facility facilitates scientific discovery and fosters the integration of new researchers into the field.