Tet proteins enhance the developmental hourglass
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Peter G Hendrickson1, Bradley R Cairns1
1Howard Hughes Medical Institute and the Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Nature Genetics
|March 30, 2016
Abstract:
A new study compares DNA methylation profiles in developing zebrafish, Xenopus tropicalis and mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylotypic period of early development. These findings provide an epigenetic underpinning for the 'hourglass' model.
