Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

735
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
735
Pedigree Analysis01:35

Pedigree Analysis

90.6K
Overview
90.6K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.7K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.7K
Atypical Pneumonia01:14

Atypical Pneumonia

13
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
13
Pleiotropy01:33

Pleiotropy

44.0K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.0K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

998
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
998

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recovery from severe adriamycin-induced cardiomyopathy after prolonged intensive care in a patient with uterine leiomyosarcoma: A case report.

Experimental and therapeutic medicine·2026
Same author

Dual-mark-guided entry technique for preventing entry-site deviation during peroral endoscopic myotomy.

Endoscopy international open·2026
Same author

Efficacy and Safety of Closure-Focused Anti-Reflux Mucoplasty Compared With Conventional ARMS: A Propensity Score-Matched Study (With Video).

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

A novel method for achieving effective hemostasis using a snare tip positioned within an outer sheath.

Endoscopy·2026
Same author

Esophageal endoscopic muscularis dissection with a tunnel-first approach for deeply invasive Barrett's adenocarcinoma.

Endoscopy·2026
Same author

Endoscopic Pseudo-dilation of Esophagogastric Junction During Peroral Endoscopic Myotomy: (With Video).

DEN open·2026
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Related Experiment Video

Updated: Mar 23, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

[Pick's disease].

Kazuki Yamamoto, Tomomi Ogihara

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |March 31, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Pick's disease, a form of frontotemporal lobar degeneration, is now pathologically defined by tau-positive Pick bodies. Previously diagnosed clinically, it presents with frontal and temporal lobe dysfunction, including behavioral variant FTD, PNFA, and SD.

    More Related Videos

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
    08:33

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

    Published on: June 25, 2019

    8.8K
    Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
    07:35

    Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

    Published on: June 23, 2015

    12.1K

    Related Experiment Videos

    Last Updated: Mar 23, 2026

    A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
    07:50

    A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

    Published on: September 20, 2018

    16.6K
    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
    08:33

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

    Published on: June 25, 2019

    8.8K
    Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
    07:35

    Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

    Published on: June 23, 2015

    12.1K

    Area of Science:

    • Neuroscience
    • Neuropathology

    Context:

    • Pick's disease is a specific clinicopathological entity within the spectrum of frontotemporal lobar degeneration (FTLD).
    • Historically, Pick's disease was diagnosed based on clinical symptoms and imaging findings of frontotemporal atrophy.
    • The definition has shifted from clinical presentation to a definitive pathological diagnosis.

    Purpose:

    • To clarify the evolving terminology and diagnostic criteria for Pick's disease.
    • To highlight the current pathological definition based on the presence of Pick bodies.
    • To outline the clinical manifestations associated with Pick's disease.

    Summary:

    • Pick's disease is characterized by localized atrophy in the frontotemporal lobe.
    • The diagnosis is now exclusively pathological, requiring the identification of tau-positive Pick bodies.
    • Clinical phenotypes include behavioral variant FTD (bvFTD), progressive nonfluent aphasia (PNFA), and semantic dementia (SD).

    Impact:

    • Establishes a clear pathological basis for Pick's disease diagnosis, distinguishing it from other FTLD subtypes.
    • Facilitates more accurate research and clinical understanding of FTLD subtypes.
    • Improves diagnostic precision and potential therapeutic targeting for patients with specific FTLD presentations.