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The antitumor effect of magnetic nanodisks and DNA aptamer conjugates
P D Kim1,2, S S Zamay1,3,4, T N Zamay5,6
1Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorogok, Krasnoyarsk, 660036, Russia.
Doklady. Biochemistry and Biophysics
|March 31, 2016
Abstract:
Here we describe a method of forming large arrays (up to 10(9) pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.

