Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

21
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
21
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

21
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
21
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

47
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
47
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.9K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K
Production of Antibiotics01:27

Production of Antibiotics

22
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
22
Antibiotic Selection00:57

Antibiotic Selection

62.0K
Overview
62.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organocatalytic Asymmetric Michael Addition/Annulation Cascade toward the β-Nitro Chromones.

The Journal of organic chemistry·2026
Same author

Combined Tribenoside/Lidocaine Rectal Cream (Procto-Glyvenol<sup>®</sup>) Promotes Tissue Repair in a Preclinical Model of Acute Complicated Anal Fissure.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Observed nitrogen accumulation during salinity and temperature surges in a coastal dam controlled lake.

Journal of environmental management·2026
Same author

Dinutuximab beta effectively treats Ewing sarcoma when combined with chemotherapy.

iScience·2026
Same author

Stereoselective Dihalogenation of Alkynes to Access Enantioenriched <i>Z</i>-Vicinal Dihaloalkene Atropisomers.

Journal of the American Chemical Society·2025
Same author

Enantioselective Synthesis of Inherently Chiral Calix[4]arenes via Catalytic Asymmetric Lower-Rim Functionalization.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Mar 23, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K

β-Lactam Antibiotics Renaissance.

Wenling Qin1, Mauro Panunzio2, Stefano Biondi3

  • 1ISOF-CNR Department of Chemistry "G. Ciamician", Via Selmi, 2 I-40126 Bologna, Italy. wenling.qin2@unibo.it.

Antibiotics (Basel, Switzerland)
|March 31, 2016
PubMed
Summary

The discovery of new beta-lactam antibiotics and beta-lactamase inhibitors is crucial due to rising bacterial resistance. Recent advancements show promising novel compounds entering clinical trials to combat infections.

Keywords:
bacterial infectionsβ-lactam antibioticsβ-lactamase inhibitors

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.6K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K

Related Experiment Videos

Last Updated: Mar 23, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.6K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Beta-lactam antibiotics, widely used since the 1940s, face significant challenges from emerging bacterial resistance.
  • The increasing prevalence of multidrug-resistant bacteria necessitates urgent development of new antibacterial agents.
  • Pharmaceutical industry withdrawal from antibiotic research exacerbates the need for novel therapeutic strategies.

Purpose of the Study:

  • To highlight recent advancements in the discovery of novel beta-lactam antibiotics.
  • To provide an overview of emerging beta-lactamase inhibitors.
  • To address the critical need for new treatments against resistant bacterial infections.

Main Methods:

  • Review of recent scientific literature and clinical trial data.
  • Analysis of emerging trends in beta-lactam antibiotic and inhibitor development.
  • Identification of promising compounds progressing through the research pipeline.

Main Results:

  • Several novel beta-lactam antibiotics have advanced into clinical trials.
  • New beta-lactamase inhibitors are under active investigation.
  • A growing pipeline of potential antibacterial agents offers hope against resistant bacteria.

Conclusions:

  • Despite challenges, significant progress is being made in developing new beta-lactam antibiotics and inhibitors.
  • These advancements are vital for combating the global threat of antibiotic resistance.
  • Continued research and development are essential to replenish the dwindling arsenal against bacterial infections.