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Related Experiment Videos

Acquired Class D β-Lactamases.

Nuno T Antunes1, Jed F Fisher2

  • 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. ngiaoant@nd.edu.

Antibiotics (Basel, Switzerland)
|March 31, 2016
PubMed
Summary
This summary is machine-generated.

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Class D β-lactamases are a growing threat, causing resistance to vital antibiotics in bacteria like Acinetobacter baumannii. This review details their characteristics, clinical concerns, and spread mechanisms.

Area of Science:

  • Microbiology and Molecular Biology
  • Antimicrobial Resistance
  • Enzymology

Background:

  • Class D β-lactamases are a significant mechanism of bacterial resistance to β-lactam antibiotics.
  • These enzymes are particularly concerning in pathogenic bacteria such as Acinetobacter baumannii and Enterobacteriaceae.
  • The emergence of plasmid-encoded Class D β-lactamases poses a substantial clinical challenge.

Purpose of the Study:

  • To provide a historical perspective on Class D β-lactamases.
  • To discuss the phenotypic and structural characteristics of Class D β-lactamases.
  • To examine the clinical relevance of plasmid-encoded Class D β-lactamases and chromosomal mobilization mechanisms.

Main Methods:

  • Literature review focusing on Class D β-lactamases.
Keywords:
OXAcarbapenemaseclass Dcrystal structurekineticsplasmidβ-lactamase

Related Experiment Videos

  • Analysis of phenotypic and structural data of these enzymes.
  • Discussion of susceptibility patterns, kinetics, and genetic mobilization mechanisms.

    • Main Results:

    • Class D β-lactamases exhibit a spectrum of activities, including narrow, extended, and carbapenemase profiles.
    • Plasmid-mediated Class D β-lactamases are of significant clinical concern due to their mobility.
    • Mechanisms for the mobilization of chromosomal Class D β-lactamases are also relevant to resistance spread.

    Conclusions:

    • Class D β-lactamases represent a critical and evolving challenge in combating bacterial infections.
    • Understanding their characteristics and spread is essential for developing effective therapeutic strategies.
    • Further research into these enzymes and their genetic elements is crucial for antimicrobial stewardship.