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Updated: Mar 23, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
T cell receptor signalling in the control of regulatory T cell differentiation and function
Ming O Li1, Alexander Y Rudensky2
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Abstract:
Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of TReg cells in the context of their function in health and disease.
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