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A uterine leiomyoma showing both t(12;14) and del(7) abnormalities
S N Sait1, P Dal Cin, S Ovanessoff
1Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Cancer Genetics and Cytogenetics
|February 1, 1989
Abstract:
The involvement of chromosomes 12 and 14 in uterine leiomyomas has been well established. However, in a recent report of only a del(7)(q22.1q31.32) or (q11.2q22.3) in two cases of typical uterine leiomyoma, Boghosian et al. hypothesized that this could represent a cytogenetic subgroup of uterine leiomyomas. We report a case of uterine leiomyoma with both the t(12;14) and del(7) in all the cells examined and discuss the implications of this in terms of critical chromosomal rearrangements underlying the route to benign cellular proliferation.