Related Experiment Video

Updated: Mar 23, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.8K

[Dyslipidemia and atherogenic risk in patients with rheumatoid arthritis]

José Antonio de Jesús Batún Garrido1, Francisco Olán1, Éufrates Hernández Núñez1

  • 1Servicio de Medicina Interna, Hospital Regional de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, El Recreo, Villahermosa, Tabasco, México.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|March 31, 2016
PubMed

Insights

Rheumatoid arthritis patients often have unhealthy lipid profiles, increasing cardiovascular risk. Early detection and management of dyslipidemia are crucial for better health outcomes.

Area of Science:

  • Cardiology
  • Rheumatology
  • Clinical Biochemistry

Background:

  • Dyslipidemia is a primary risk factor for atherosclerotic cardiovascular disease.
  • Rheumatoid arthritis patients exhibit a 2-3 fold increased cardiovascular risk.
  • This heightened risk is partly attributed to lipid patterns that elevate the atherogenic index.

Purpose of the Study:

  • To investigate the prevalence and characteristics of dyslipidemia in rheumatoid arthritis patients.
  • To assess the relationship between rheumatoid arthritis disease activity, serological markers, and lipid profiles.
  • To evaluate atherogenic indices and the impact of specific medications on lipid profiles in this cohort.

Main Methods:

  • A descriptive, cross-sectional, observational, and prospective study involving 82 rheumatoid arthritis patients.
  • Data collection included patient demographics, disease characteristics, medication use, and lipid profiles.
  • Statistical analysis employed Chi-square and Mann-Whitney tests to evaluate categorical and continuous variables, respectively.

Main Results:

  • The frequency of dyslipidemia was 54.9%, predominantly in the 51-60 age group.
  • Higher dyslipidemia rates were observed in patients with obesity type I, positive rheumatoid factor, and elevated inflammatory markers (ESR, CRP).
  • Mean atherogenic indices (Castelli I: 4.36, Kannel: 2.59, TG/HDL-c: 3.83) indicated a pro-atherogenic profile. Hydroxychloroquine use was associated with lower dyslipidemia frequency.

Conclusions:

  • Rheumatoid arthritis patients possess a pro-atherogenic lipid profile, contributing to increased cardiovascular risk.
  • Understanding and managing dyslipidemia in rheumatoid arthritis is essential for cardiovascular risk reduction.
  • Targeted lipid management strategies should be considered in the comprehensive care of rheumatoid arthritis patients.
Abstract

Keywords:
Artritis reumatoideAtherogenic indexDislipidemiaDyslipidaemiaRheumatoid arthritisÍndice aterogénico

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

1.3K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.4K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
576
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
821
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
970
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.9K
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
441