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Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule.

S Benchimol1, A Fuks, S Jothy

  • 1Cancer Centre, McGill University, Montreal, Quebec, Canada.

Cell
|April 21, 1989

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View abstract on PubMed

Summary
This summary is machine-generated.

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  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Carcinoembryonic Antigen, A Human Tumor Marker, Functions As An Intercellular Adhesion Molecule.

    • Carcinoembryonic antigen (CEA) mediates cell aggregation and sorting, revealing its role as an intercellular adhesion molecule. Its localization shifts in tumors, impacting tissue architecture.

    Area of Science:

    • Oncology
    • Cell Biology
    • Biochemistry

    Background:

    • Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in various carcinomas.
    • Understanding CEA's function is crucial for its role in malignant transformation.

    Purpose of the Study:

    • To investigate the functional role of CEA in cell adhesion and tissue organization.
    • To explore CEA's localization in normal and cancerous intestinal epithelium.

    Main Methods:

    • Cell aggregation assays using colon adenocarcinoma cells (LS-180) and transfected rodent cells.
    • Analysis of CEA localization via immunofluorescence in adult, embryonic, and tumor tissues.

    Main Results:

    • CEA mediates calcium-independent, homotypic cell aggregation.
    • CEA facilitates homotypic cell sorting in mixed cell populations.
    • CEA exhibits altered membrane localization in colonic tumors and embryonic intestine compared to adult intestine.

    Conclusions:

    • CEA functions as an intercellular adhesion molecule.
    • CEA's altered localization contributes to aberrant tissue architecture in colonic tumors.
    • A model for CEA's role in intestinal tissue architecture is proposed.

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