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Antiproliferative mechanism of anti-class II monoclonal antibodies

L Vaickus1, V E Jones, C L Morton

  • 1Department of Medicine, University of Iowa College of Medicine, Iowa City.

Cellular Immunology
|April 1, 1989
PubMed

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Overview
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Antibody Structure and Classes

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Antibody Actions

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Neutralization
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