GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line
Maryam Bikhof Torbati1, Masoud Ebrahimian2, Mohammad Yousefi2
1a Department of Biology , College of science, Yadegar-e-Imam Khomeini(RAH) Shahr-e-rey Branch, Islamic Azad University , Tehran , Iran.
Abstract:
The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on this type of nanocarrier and to determine the actual effect of any drugs encapsulated on it. The cytotoxic effects of GO-PEG nanosheets were evaluated on HeLa cell line by MTT assay. The results exhibited cytotoxic property of PEGylated GO drug nanocarrier significantly is dose dependent and incubation time dependent.
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