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Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Chiara Nosarti1, Seán Froudist-Walsh1

  • 1Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

Developmental Medicine and Child Neurology
|March 31, 2016
PubMed

Insights

Children born very preterm (VPT) show memory deficits impacting daily life. Neuroimaging studies reveal brain alterations linked to memory development, potentially guiding future interventions for VPT individuals.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Children born very preterm (VPT) often experience memory function deficits.
  • These deficits can significantly affect academic and daily life functioning.
  • The neuroanatomical basis of memory development in VPT individuals remains poorly understood.

Purpose of the Study:

  • To explore the neuroanatomical substrates of episodic and working memory in very preterm (VPT) born individuals.
  • To integrate findings from functional and structural magnetic resonance imaging (MRI) studies.
  • To understand the relationship between brain alterations in VPT individuals and typical memory network development.

Main Methods:

  • Review of recent functional MRI studies.
  • Review of recent structural MRI studies.
  • Contrast of findings from episodic and working memory research.

Main Results:

  • Identified alterations in brain structures and networks supporting memory in VPT individuals.
  • Highlighted differences between episodic and working memory neurodevelopmental trajectories.
  • Established links between brain alterations and memory deficits in VPT populations.

Conclusions:

  • Neuroimaging reveals key differences in memory network development in VPT individuals.
  • Understanding these differences may inform targeted interventions.
  • Specific time windows for effective working memory interventions may be identifiable.

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