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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Glomerular cell crosstalk.

Rachel Lennon¹, Salman Hosawi

¹aWellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences bInstitute of Human Development, Faculty of Human Sciences, University of Manchester cDepartment of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester, UK dDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Current Opinion in Nephrology and Hypertension

|March 31, 2016

Summary

This summary is machine-generated.

Glomerular cells communicate through novel signaling pathways, involving secreted ligands and extracellular vesicles. Understanding this crosstalk offers new therapeutic avenues for kidney diseases.

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Area of Science:

Nephrology
Cell Biology
Molecular Signaling

Background:

Glomerular filtration relies on specialized cells within microscopic kidney organelles.
Efficient cell-to-cell communication is crucial for glomerular adaptation to mechanical stress.
Disruptions in glomerular cell signaling can lead to disease pathogenesis.

Purpose of the Study:

To review recent discoveries in signaling events mediating glomerular cell crosstalk.
To explore how disease processes impact normal glomerular cell regulation.
To highlight potential therapeutic strategies targeting glomerular cell communication.

Main Methods:

Literature review of recent studies on glomerular cell signaling.
Analysis of autocrine and paracrine signaling mechanisms.
Examination of the role of the extracellular matrix and extracellular vesicles in signal transmission.

Main Results:

Glomerular cell crosstalk involves numerous secreted signaling ligands acting in autocrine/paracrine manners.
Classical signaling molecules have expanded roles, and new therapeutic strategies are emerging.
The glomerular extracellular matrix acts as a signaling ligand reservoir, and extracellular vesicles facilitate intercellular communication.

Conclusions:

Recent advances enhance understanding of glomerular cell crosstalk, focusing on growth factors and signaling peptides.
Delivery methods to target cells and potential therapies for glomerular diseases are discussed.
Targeting cell crosstalk presents a promising approach for novel therapeutic interventions in kidney disease.