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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
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Epigenetic Mechanisms in Asthma.

Avery DeVries1,2, Donata Vercelli2,3,4,5

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Epigenetic changes, like DNA methylation, are being investigated for their role in childhood asthma and allergies. Early epigenetic predictors may reveal how susceptibility to these common diseases develops.

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Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Epigenetics
  • Chronic Disease Pathogenesis

Background:

  • Asthma and allergic diseases are leading chronic childhood noncommunicable diseases.
  • The precise pathogenetic mechanisms underlying these conditions remain largely unknown.
  • Epigenetic mechanisms, which mediate gene-environment interactions, are increasingly studied in asthma and allergy.

Purpose of the Study:

  • To investigate the role of epigenetic mechanisms in the pathogenesis of childhood asthma and allergic diseases.
  • To identify early epigenetic predictors of asthma development and susceptibility.
  • To understand the significance of DNA methylation signatures in relation to asthma.

Main Methods:

  • Identification of DNA methylation signatures associated with asthma.
  • Characterization of early epigenetic markers predictive of asthma.
  • Analysis of epigenetic mechanisms linking environmental cues to disease development.

Main Results:

  • DNA methylation signatures linked to concurrent asthma and its development in childhood have been identified.
  • The clinical interpretability of these identified signatures is currently limited.
  • Early epigenetic predictors suggest a role for epigenetics in disease inception and susceptibility.

Conclusions:

  • Epigenetic mechanisms, particularly DNA methylation, are implicated in the development of childhood asthma and allergies.
  • Further research into early epigenetic predictors is crucial for understanding disease susceptibility.
  • Epigenetics offers potential insights into the regulation of asthma onset and risk.