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Related Experiment Videos

Left ventricular function during sepsis.

H Artucio1, A Digenio, M Pereyra

  • 1Intensive Care Unit, University Hospital, Universidad de la República, Facultad de Medicina, Montevideo, Uruguay.

Critical Care Medicine
|April 1, 1989
PubMed
Summary

Left ventricular dysfunction is common in sepsis patients without shock, impacting survival. Abnormal systolic time intervals, specifically the preejection period/left ventricular ejection time ratio, indicate high mortality risk.

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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Physiology

Background:

  • Sepsis can lead to multi-organ dysfunction, including cardiac impairment.
  • Left ventricular dysfunction in sepsis, even without shock, may influence patient outcomes.
  • Assessing cardiac function is crucial for risk stratification in septic patients.

Purpose of the Study:

  • To investigate the prevalence of left ventricular dysfunction in septic patients without shock.
  • To determine the prognostic significance of left ventricular impairment in this patient population.
  • To evaluate the utility of systolic time intervals (STI) in assessing cardiac function and predicting mortality in sepsis.

Main Methods:

  • Studied 49 septic patients without shock, assessing left ventricular function using systolic time intervals (STI).

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  • Utilized the preejection period/left ventricular ejection time ratio (PEP/LVET) to quantify left ventricular function.
  • Divided patients into groups based on PEP/LVET ratio to analyze mortality rates.

    • Main Results:

    • Septic patients without shock exhibited abnormal PEP/LVET ratios, indicating widespread left ventricular dysfunction.
    • A higher PEP/LVET ratio (greater than 0.42) was significantly associated with increased mortality (75% vs. 30%).
    • The PEP/LVET ratio demonstrated 55% sensitivity, 85% specificity, and 75% positive predictive value for identifying high-risk patients.

    Conclusions:

    • Left ventricular dysfunction is prevalent in septic patients without shock.
    • The PEP/LVET ratio is a valuable tool for identifying septic patients with severe left ventricular impairment and high mortality risk.
    • STI measurements can aid in risk stratification and management of septic patients.