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Related Experiment Videos

Orocecal transit delay in obese patients.

G Basilisco1, G Camboni, A Bozzani

  • 1Cattedra di Patologia Medica III, Istituto di Scienze Mediche, Milano, Italy.

Digestive Diseases and Sciences
|April 1, 1989
PubMed
Summary

Obese patients exhibit significantly longer orocecal transit times compared to healthy individuals. Naloxone administration further delayed this transit time in obese subjects, indicating its impact on gastrointestinal motility.

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Area of Science:

  • Gastroenterology
  • Human Physiology
  • Pharmacology

Background:

  • Obesity is associated with altered gastrointestinal function.
  • Orocecal transit time (OCTT) is a key indicator of gastrointestinal motility.

Purpose of the Study:

  • To assess OCTT in obese patients.
  • To investigate the effect of naloxone on OCTT in obese individuals.

Main Methods:

  • Lactulose hydrogen breath test used to measure OCTT.
  • Double-blind, randomized, placebo-controlled study design.
  • Comparison between 12 obese patients and 22 healthy controls.

Main Results:

  • Obese patients had significantly longer OCTT (median 130 min) than healthy controls (median 75 min).

Related Experiment Videos

  • Naloxone (40 µg/kg/hr IV) significantly delayed OCTT in obese patients (median 150 min) compared to placebo.

    • Conclusions:

    • Obese individuals demonstrate delayed orocecal transit.
    • Naloxone may impede gastrointestinal motility in obese subjects.