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Related Experiment Videos

Ascorbic acid absorption in Crohn's disease. Studies using L-[carboxyl-14C]ascorbic acid.

S H Pettit1, J L Shaffer, C W Johns

  • 1Department of Surgery, Hope Hospital, University of Manchester School of Medicine, Salford, United Kingdom.

Digestive Diseases and Sciences
|April 1, 1989
PubMed
Summary
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This study found that intestinal absorption and total body levels of ascorbic acid (vitamin C) are normal in Crohn's disease patients, regardless of fistulas. Routine vitamin C supplements are likely unnecessary for these patients.

Area of Science:

  • Gastroenterology and Nutrition

Background:

  • Crohn's disease can affect nutrient absorption.
  • Ascorbic acid (vitamin C) is essential for tissue repair and immune function, particularly relevant in inflammatory conditions like Crohn's disease.

Purpose of the Study:

  • To investigate the total body pool and intestinal absorption of ascorbic acid in patients with Crohn's disease, with and without fistulae, compared to healthy controls.

Main Methods:

  • Oral administration of L-[carboxyl-14C]Ascorbic acid to patients and controls.
  • Assessment of intestinal absorption via cumulative urinary 14C recovery.
  • Calculation of total body pools using plasma 14C decay curves.

Main Results:

  • Intestinal absorption rates of ascorbic acid were similar across groups: Crohn's with fistulae (73.9%), Crohn's without fistulae (72.8%), and controls (80.3%).

Related Experiment Videos

  • Total body pools of ascorbic acid were also comparable: Crohn's with fistulae (17.1 mg/kg), Crohn's without fistulae (9.6 mg/kg), and controls (13.3 mg/kg).

    • Conclusions:

    • Ascorbic acid absorption and body pool are normal in patients with Crohn's disease, even with fistulizing complications.
    • Routine vitamin C supplementation is not indicated unless dietary intake is insufficient.