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Circulating miR155 expression level is positive with blood pressure parameters: Potential markers of target-organ

Yuqing Huang1, Jiyan Chen1, Yingling Zhou1

  • 1a Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences , The First Affiliated Hospital of South China University of Technology , Guangzhou , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|March 31, 2016
PubMed

Insights

MicroRNA 155 (miR155) is significantly elevated in hypertensive patients and correlates with blood pressure and left ventricular hypertrophy. This suggests miR155 may serve as a non-invasive biomarker for hypertension and target organ damage.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular hypertrophy (LVH) is a common complication of hypertension.
  • Novel non-invasive biomarkers are needed for early detection and management of hypertension and its complications.

Purpose of the Study:

  • To investigate the association between microRNA 155 (miR155) expression levels and blood pressure (BP) parameters.
  • To evaluate the relationship of miR155 with left ventricular hypertrophy (LVH) in patients with essential hypertension.
  • To explore the potential of miR155 as a non-invasive biomarker for hypertension and target organ damage (TOD).

Main Methods:

  • Assessed miR155 expression using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in 50 hypertensive patients and 30 healthy controls.
  • Measured office and 24-hour ambulatory blood pressure monitoring (ABPM) parameters.
  • Evaluated left ventricular mass index (LVMI) via two-dimensional echocardiography.
  • Correlated miR155 levels with BP parameters and LVMI using Spearman correlation coefficient.

Main Results:

  • Hypertensive patients exhibited significantly higher miR155 expression compared to healthy controls (p < 0.001).
  • Elevated miR155 levels were also observed in patients with LVH compared to those without (p < 0.001).
  • miR155 expression showed significant positive correlations with office BP (SBP, DBP, PP) and 24-h ABPM parameters (mean SBP, DBP, PP), as well as with LVMI (all p < 0.05).

Conclusions:

  • Circulating miR155 is upregulated in essential hypertension.
  • miR155 expression levels correlate positively with blood pressure and left ventricular hypertrophy.
  • miR155 may serve as a potential non-invasive biomarker for hypertension and associated target organ damage.
Abstract

Keywords:
Essential hypertensionleft ventricular hypertrophymiR155

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