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Updated: Mar 23, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Empirical Antibiotic Therapy for Ventilator-Associated Pneumonia
Joseph M Swanson1, Diana L Wells2
1College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., Suite 203, Memphis, TN 38632, USA. jswanson@uthsc.edu.
Abstract:
Ventilator-associated pneumonia (VAP) is the most common infectious complication in the intensive care unit. It can increase duration of mechanical ventilation, length of stay, costs, and mortality. Improvements in the administration of empirical antibiotic therapy have potential to reduce the complications of VAP. This review will discuss the current data addressing empirical antibiotic therapy and the effect on mortality in patients with VAP. It will also address factors that could improve the administration of empirical antibiotics and directions for future research.
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