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Updated: Mar 23, 2026

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications
Published on: July 14, 2017
[Current status of urinary iodine analysis and its clinical interest]
Radhouene Doggui1, Myriam El Ati-Hellal2, Jalila El Ati1
1Laboratoire de surveillance et d'épidémiologie nutritionnelles en Tunisie, Institut national de nutrition et de technologie alimentaire, Bab Saadoun-Tunis, Tunisie.
Abstract:
Iodine deficiency especially during pregnancy causes neurological disorders in the fetus. Actually, about two billion people are suffering from iodine deficiency through the world. The assessment of iodine intake is based on the determination of urinary iodine in the target population. Despite the complexity of the urinary matrix, a reliable assay must be achieved. After a review of pathophysiological interest of urinary iodine, various techniques for its measurement and their analytical performance were analyzed in order to select a reliable technique and enhance results interpretation.
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