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Related Concept Videos

Viral Mutations00:36

Viral Mutations

40.7K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Mutations in Microorganisms01:18

Mutations in Microorganisms

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Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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Related Experiment Video

Updated: Mar 23, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

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ZIKA--How fast does this virus mutate?

Ian S Logan1

  • 1Parkside Drive, Exmouth, Devon, UK EX8 4LB. ianlogan22@btinternet.com.

Dong Wu Xue Yan Jiu = Zoological Research
|April 1, 2016
PubMed
Summary
This summary is machine-generated.

Researchers analyzed Zika virus evolution using mitochondrial DNA techniques. The study revealed a rapid mutation rate, crucial for tracking the epidemic

Keywords:
Mutation ratePhylogenetic treePolyproteinVirusZika

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Area of Science:

  • Virology
  • Epidemiology
  • Genetics

Background:

  • The Zika virus epidemic was declared a Public Health Emergency of International Concern by the World Health Organization.
  • The virus spread rapidly across South and Central America, infecting over a million people.
  • Zika virus is neurotropic, linked to fetal birth defects and Guillain-Barré syndrome in adults.

Purpose of the Study:

  • To apply mitochondrial DNA analysis techniques to the Zika virus.
  • To demonstrate phylogenetic tree construction for viral evolution.
  • To measure the mutation rate of the Zika virus.

Main Methods:

  • Utilized techniques developed for mitochondrial DNA studies.
  • Applied these methods to analyze the Zika virus genome.
  • Constructed a phylogenetic tree to visualize viral relationships.

Main Results:

  • The Zika virus mutation rate was determined to be between 12 and 25 bases per year.
  • The viral genome size is 10,272 bases.
  • A method for constructing phylogenetic trees and measuring mutation rates was successfully applied.

Conclusions:

  • The rapid mutation rate of Zika virus facilitates geographic spread monitoring.
  • Understanding mutation rates aids in evaluating the effectiveness of preventative measures.
  • Phylogenetic analysis provides insights into viral evolution during epidemics.