Related Experiment Video
Updated: Mar 23, 2026
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
[. Role of molecular and genetic factors in survival from uveal melanoma]
S V Saakyan1, A Yu Tsygankov2, A G Amiryan3
1Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of Russia, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062; Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya St., Moscow, Russian Federation 127473.
Aim:
to analyze survival rates in uveal melanoma (UM) patients and establish correlations with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation.
Material And Methods:
Methylation-specific PCR analysis was performed in 104 patients with histologically verified UM.
Results:
A statistically significant correlation has been found between chromosome 3 monosomy, on the one hand, and mixed/epithelioid cell melanomas and ciliary body involvement, on the other. As for chromosome 1p deletion, it has demonstrated association with extrabulbar tumor growth. We have also calculated 5-year survival and mortality rates in «large» UMs and their relationship with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation.
Conclusion:
Chromosome 3 monosomy is associated with lower survival rates, while RASSF1A methylation - with a better prognosis. A combination of molecular and genetic changes (particularly, chromosome 3 monosomy and chromosome 1p deletion) also leads to reduced survival in UM patients.
Related Concept Videos
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:23Abnormal Proliferation
02:59Cancer Prevention
Some...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:53Adaptive Mechanisms in Cancer Cells
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...