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Updated: Mar 23, 2026
Opsonophagocytic Killing Assay to Assess Immunological Responses Against Bacterial Pathogens
Published on: April 5, 2019
Opsonophagocytic Assay To Evaluate Immunogenicity of Nontyphoidal Salmonella Vaccines
Girish Ramachandran1,2, Mary Adetinuke Boyd1,3, Jennifer MacSwords1,2
1Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract:
Nontyphoidal Salmonella (NTS) invasive infections are an important cause of morbidity and mortality in sub-Saharan Africa. Several vaccines are in development to prevent these infections. We describe an NTS opsonophagocytic killing assay that uses HL-60 cells and baby rabbit complement to quantify functional antibodies elicited by candidate NTS vaccines.
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