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Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus

Wing Yan So1, Po Sing Leung1

  • 1School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong, China.

Medicinal Research Reviews
|April 1, 2016
PubMed

Insights

Fibroblast growth factor (FGF) 21 is a key metabolic regulator, but resistance can occur. This review explores FGF21

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Molecular Biology

Background:

  • Fibroblast growth factor (FGF) 21 is an endocrine hormone primarily from the liver.
  • FGF21 plays a crucial role in regulating glucose and lipid homeostasis.
  • Therapeutic potential for metabolic disorders like obesity and diabetes is recognized, yet FGF21 resistance is a challenge.

Purpose of the Study:

  • To critically appraise recent advances in understanding FGF21 production and action.
  • To review the antidiabetic effects and clinical implications of FGF21.
  • To discuss engineered FGF21 analogs in diabetes management and potential side effects.

Main Methods:

  • Literature review of physiological regulation of FGF21.
  • Analysis of preclinical and clinical trial data for FGF21 analogs.
  • Critical appraisal of existing research on FGF21 resistance.

Main Results:

  • FGF21 production is regulated under various physiological conditions.
  • FGF21 demonstrates significant antidiabetic actions.
  • Engineered FGF21 analogs show promise but require careful evaluation for side effects.

Conclusions:

  • Understanding FGF21 regulation and resistance is vital for therapeutic development.
  • FGF21 analogs offer potential for diabetes management.
  • Further research is needed to optimize FGF21-based therapies and mitigate risks.
Keywords:
FGF21 analogsglucoselipid metabolismpancreasperoxisome proliferator-activated receptor gamma

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