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HIV, HBV and HCV Coinfection Prevalence in Iran--A Systematic Review and Meta-Analysis

Fahimeh Bagheri Amiri1,2, Ehsan Mostafavi1,3,4, Ali Mirzazadeh5,4

  • 1Department of Epidemiology, Pasteur Institute of Iran, Tehran, Iran.

Plos One
|April 1, 2016
PubMed

Insights

People who inject drugs (PWID) in Iran are disproportionately affected by HIV, hepatitis B (HBV), and hepatitis C (HCV) coinfections. Enhanced screening is crucial to prevent new infections and reduce transmission among this vulnerable population.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Hepatitis B (HBV) and hepatitis C (HCV) are common coinfections with human immunodeficiency virus (HIV), posing significant survival threats to HIV-infected individuals.
  • Estimating the prevalence of these coinfections in Iran is critical for public health strategies.

Purpose of the Study:

  • To estimate the prevalence of HIV, HBV, HCV, and their coinfections (HIV/HCV, HIV/HBV, and triple infections) in various subpopulations within Iran.

Main Methods:

  • A systematic review and meta-analysis adhering to PRISMA guidelines was conducted.
  • Literature from January 1996 to March 2012 was systematically searched in English and Persian/Farsi databases.
  • Prevalence data for HIV, HBV, and HCV antibodies/antigens were extracted and reported with 95% confidence intervals.

Main Results:

  • HIV prevalence ranged from 0% in the general population to 17.25% in people who inject drugs (PWID).
  • HBV prevalence was highest in PWID (30.9%), and HCV prevalence was also highest in PWID (51.46%).
  • Coinfections were zero in the general population and healthcare workers, but common in PWID: HIV/HCV (10.95%), HIV/HBV (1.88%), and triple infections (1.25%).

Conclusions:

  • People who inject drugs (PWID) are severely and disproportionately impacted by HIV, HBV, and HCV coinfections in Iran.
  • Reinforcing screening for these coinfections is essential for prevention and reducing transmission within this community and to others.
Abstract

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