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Value of serum 125Ca levels: does the result preclude second look?
1Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.
Gynecologic Oncology
|May 1, 1989
Summary
This study evaluated the CA 125 tumor marker in ovarian cancer patients undergoing reoperation. While CA 125 showed high positive predictive value, it was not fully predictive of successful tumor removal.
Area of Science:
- Oncology
- Surgical Oncology
- Gynecologic Oncology
Background:
- Ovarian cancer recurrence often necessitates reoperative surgery.
- Assessing disease status and resectability preoperatively is crucial for patient management.
- The role of CA 125 in predicting outcomes of reoperation requires further clarification.
Purpose of the Study:
- To evaluate the predictive value of preoperative CA 125 levels in patients with ovarian cancer undergoing reoperative surgery.
- To determine the correlation between CA 125 levels and the presence of gross disease or resectability during reoperation.
Main Methods:
- Retrospective analysis of 45 women with a history of ovarian cancer undergoing reoperative surgery.
- Preoperative serum CA 125 levels were measured.
- Operative findings regarding gross disease and resectability were recorded.
Main Results:
- The CA 125 assay demonstrated a 100% positive predictive value and a 54% negative predictive value for detecting persistent disease.
- Twenty out of 45 patients had gross disease present at reoperation.
- CA 125 levels were not predictive of the potential for re-resectability to no gross disease.
Conclusions:
- Preoperative CA 125 levels are highly indicative of persistent ovarian cancer but do not reliably predict the extent of resectable disease.
- Further investigations are needed to optimize the selection of patients for reoperative surgery based on tumor markers and clinical factors.