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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Targeted Therapy of HER2-Negative Breast Cancer

Florian Schütz1, Christoph Domschke, Andreas Schneeweiss

  • 1University Hospital Heidelberg, Breast Unit, National Center for Tumor Diseases, Heidelberg, Germany.

Oncology Research and Treatment
|April 1, 2016
PubMed

Insights

Personalized medicine in oncology, particularly for HER2-negative breast cancer, remains limited. The lack of predictive factors hinders individualized treatment selection for targeted therapies.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Personalized and targeted treatments are key topics in oncology.
  • Current standard of care includes few targeted therapies for HER2-negative breast cancer.
  • Estrogen receptor (ER) targeted therapies are an exception, but predictive factors are often missing.

Purpose of the Study:

  • To assess the current status of personalized medicine in oncology.
  • To highlight the gap in predictive factors for targeted therapies.
  • To emphasize the need for comparative studies of new cancer drugs.

Main Methods:

  • Review of current targeted therapies in oncology.
  • Analysis of the availability of predictive factors for these therapies.
  • Discussion of the development pipeline for new cancer drugs.

Main Results:

  • Only a limited number of targeted therapies are in routine use for HER2-negative breast cancer.
  • Predictive factors are largely absent for most targeted agents, including ER-targeted treatments.
  • Numerous new drugs are in development without cross-comparison, complicating future treatment choices.

Conclusions:

  • Individualized cancer treatment is not yet standard practice.
  • There is an urgent need for predictive factors to guide the selection of targeted therapies.
  • Comparative studies are essential for future drug development and personalized oncology.

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