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Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)
H G Brunner1, R G Korneluk, M Coerwinkel-Driessen
1Department of Human Genetics, University of Nijmegen, Radboud Hospital, The Netherlands.
Human Genetics
|March 1, 1989
Abstract:
We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.