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Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability

Ghasem Mosayebi1, Mohammad Reza Soleyman1, Mostafa Khalili1

  • 1Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

International Neurourology Journal
|April 2, 2016
PubMed
Abstract

Insights

Experimental autoimmune encephalomyelitis (EAE) in rats impairs hippocampal synaptic transmission and long-term potentiation (LTP), potentially explaining memory deficits in multiple sclerosis (MS) models.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Background:

  • Multiple sclerosis (MS) is a central nervous system inflammatory disease.
  • MS commonly causes memory deficits.
  • Experimental autoimmune encephalomyelitis (EAE) models MS and impairs hippocampal learning and memory.

Purpose of the Study:

  • To investigate in vivo electrophysiological changes in synaptic transmission.
  • To evaluate synaptic plasticity in the CA1 region of the hippocampus in EAE rats.

Main Methods:

  • Recording field excitatory postsynaptic potentials (fEPSPs) in the CA1 region of EAE rat hippocampi.
  • Stimulating Schaffer collaterals and recording from stratum radiatum neurons.
  • Analyzing synaptic transmission and long-term potentiation (LTP).

Main Results:

  • EAE significantly impairs synaptic transmission and LTP in the hippocampus.
  • A decrease in paired-pulse index at 120 msec interstimulus interval was observed in EAE rats.
  • Findings suggest EAE suppresses synaptic transmission and LTP via enhanced GABAB receptor inhibition of glutamate-mediated EPSPs.

Conclusions:

  • Inflammation-driven mechanisms in EAE negatively impact synaptic transmission.
  • These synaptic changes likely contribute to the observed learning impairments in EAE rats.
  • This study provides the first in vivo electrophysiological evidence of synaptic dysfunction in EAE.
Keywords:
Encephalomyelitis, Autoimmune, ExperimentalHippocampusLong-term PotentiationPaired Pulse Index

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