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Related Concept Videos

Connective Tissue Cell Types01:22

Connective Tissue Cell Types

4.5K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Embryonic Connective Tissues01:20

Embryonic Connective Tissues

7.2K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
7.2K
Introduction to Connective Tissues01:11

Introduction to Connective Tissues

20.1K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
20.1K
Loose Connective Tissue01:26

Loose Connective Tissue

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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
11.2K
Classification of Connective Tissues01:30

Classification of Connective Tissues

21.0K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
21.0K
Tissue Transplantation01:24

Tissue Transplantation

1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K

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A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
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Pediatric Mixed Connective Tissue Disease.

Roberta A Berard1,2, Ronald M Laxer3,4

  • 1Section of Rheumatology, Children's Hospital, London Health Sciences Centre, 800 Commissioners Road East, PO Box 5010, N6A5W9, London, Ontario, Canada. roberta.berard@lhsc.on.ca.

Current Rheumatology Reports
|April 2, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric-onset mixed connective tissue disease (MCTD) requires accurate diagnosis to prevent long-term harm. Advances in understanding MCTD offer opportunities for better prognostication and targeted therapies.

Keywords:
EtiopathogenesisMixed connective tissue diseaseOutcomePediatricTreatment

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Area of Science:

  • Pediatric rheumatology
  • Rare diseases
  • Autoimmune disorders

Background:

  • Pediatric-onset mixed connective tissue disease (MCTD) is a rare autoimmune condition.
  • MCTD presents with overlapping features of arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis.
  • Early and accurate diagnosis is crucial to mitigate long-term morbidity in affected children.

Purpose of the Study:

  • To highlight the importance of accurate recognition and diagnosis of pediatric-onset MCTD.
  • To emphasize the potential of genetic and immunologic research in improving prognostication and therapy.
  • To advocate for the establishment of a multinational patient cohort for enhanced research.

Main Methods:

  • Review of current understanding of pediatric-onset MCTD.
  • Discussion of advances in genetic and immunologic research.
  • Proposal for the development of a multinational patient cohort.

Main Results:

  • Current understanding of pediatric-onset MCTD is limited by its rarity.
  • Genetic and immunologic insights offer promise for future therapeutic strategies.
  • A multinational cohort is needed to gather comprehensive data.

Conclusions:

  • Accurate diagnosis of pediatric-onset MCTD is essential for optimal patient outcomes.
  • Further research into the etiopathogenesis of MCTD can lead to improved treatments.
  • Establishing a global patient registry is vital for advancing the care and understanding of this rare disease.