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Related Experiment Videos

Dark-rearing interference with emmetropization in the rhesus monkey.

D L Guyton1, P R Greene, R T Scholz

  • 1Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Investigative Ophthalmology & Visual Science
|April 1, 1989
PubMed
Summary

Dark rearing in infant monkeys significantly increases hyperopia, a condition where distant objects are seen more clearly than near ones. This finding suggests dark rearing may help create animal models for studying hyperopia.

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Area of Science:

  • Ophthalmology
  • Animal Models
  • Developmental Biology

Background:

  • Dark rearing has previously shown protective effects against myopia development in some animal models.
  • Previous studies indicate dark-reared animals often exhibit hyperopia compared to light-reared controls.
  • The specific time course of refractive changes during dark rearing has not been well-documented in primates.

Purpose of the Study:

  • To investigate the longitudinal refractive changes in infant rhesus monkeys subjected to dark rearing.
  • To compare the refractive development of dark-reared monkeys with normative data from light-reared monkeys.
  • To assess the potential of dark rearing for creating animal models of hyperopia.

Main Methods:

  • Five infant rhesus monkeys were dark-reared from birth.

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  • Cycloplegic retinoscopies were performed bi-weekly to measure refractive error.
  • Data were compared with cross-sectional measurements from 18 normally reared monkeys.

    • Main Results:

    • Dark-reared monkeys exhibited significantly higher average hyperopia (+5.3 diopters) between 30-81 days compared to normal monkeys (+2.8 diopters).
    • Three out of five dark-reared monkeys maintained an average hyperopia of 7.0 diopters.
    • Dark rearing appeared to slow or halt the typical reduction of hyperopia observed in normally developing monkeys.

    Conclusions:

    • Dark rearing in infant rhesus monkeys leads to sustained or increased hyperopia.
    • This method shows promise for developing animal models with significant hyperopia (+5 to +8 diopters).
    • Further research can explore the mechanisms underlying dark-rearing-induced hyperopia.