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Advances in Drug Delivery Systems, from 0 to 3D superstructures
Marius Radulescu1, Simona Popescu1, Denisa Ficai1
1POLITEHNICA University of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Polizu Str., 011061 Bucharest, Romania.
Current Drug Targets
|April 2, 2016
Summary
This review explores drug delivery systems (DDS), focusing on how their dimensionality (0D to 3D) impacts therapeutic applications. Understanding DDS structure is key for effective disease treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmacology
Background:
- Nanomedicine utilizes diverse materials (organic/inorganic, polar/non-polar, micro/nanomaterials, 0D-3D) for therapeutic drug delivery systems (DDS).
- Existing literature extensively covers various DDS materials and their properties.
- However, a holistic analysis of dimensionality's role in DDS is limited.
Purpose of the Study:
- To provide a comprehensive overview of drug delivery systems.
- To examine aspects including delivery mechanisms, support materials, active agents, and disease applications.
- To highlight the significance of dimensionality in DDS design and function.
Main Methods:
- Literature review focusing on drug delivery systems.
- Analysis of DDS based on dimensionality (0D, 1D, 2D, 3D).
- Discussion of synthesis, characteristics, and applications of various DDS.
Main Results:
- Drug delivery systems can be tailored by dimensionality, active agents, and delivery mechanisms.
- System size and morphology are critical for cellular internalization, particularly in tumor cells.
- Support material nature, polarity, porosity, and pore size influence DDS performance.
Conclusions:
- This review offers a novel perspective on drug delivery systems by focusing on dimensionality.
- It emphasizes the importance of the holistic analysis of DDS dimensionality and delivery characteristics.
- Understanding dimensionality is crucial for optimizing therapeutic efficacy and targeted delivery.
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