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Cancer and Chemokines
Nicoletta Caronni1,2, Benedetta Savino3,4, Camilla Recordati5
1Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, I-20089, Milano, Italy.
Methods in Molecular Biology (Clifton, N.J.)
|April 2, 2016
Summary
Chemokines, crucial for directing cell movement, play a significant role in cancer. This study explores methods to investigate their impact on tumor spread and immune cell infiltration in mouse models.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- Chemokines are secreted cytokines that guide leukocyte migration.
- Cancer cells and the tumor microenvironment express chemokines and their receptors.
- These molecules influence immune cell infiltration, angiogenesis, tumor growth, and metastasis.
Purpose of the Study:
- To describe technical approaches for studying chemokines in cancer.
- To elucidate the role of chemokines in leukocyte infiltration and tumor metastasis.
- To provide insights into cancer-related inflammation mediated by chemokines.
Main Methods:
- Utilizing murine tumor models.
- Investigating chemokine expression at the tumor site.
- Analyzing chemokine receptor expression by tumor cells.
- Studying technical approaches for evaluating leukocyte infiltration and metastasis.
Main Results:
- Chemokines dictate leukocyte infiltration and angiogenesis at the tumor site.
- Tumor cell chemokine receptor expression promotes growth and metastasis.
- Chemokines contribute indirectly to tumor growth and cancer-related inflammation.
Conclusions:
- Chemokines are key regulators of the tumor microenvironment.
- Understanding chemokine roles is vital for cancer research and therapy.
- Technical approaches in murine models are essential for studying these mechanisms.
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