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Updated: Mar 23, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Nucleic-Acid Delivery Using Lipid Nanocapsules.

Frederic Lagarce¹, Catherine Passirani

¹Inserm U1066 Mint, LUNAM Université, Angers, France. frederic.lagarce@univ-angers.fr.

Current Pharmaceutical Biotechnology

|April 2, 2016

Summary

Lipid nanocapsules (LNCs) are effective carriers for delivering nucleic acids in cancer therapy. These nanocarriers show promise for treating glioma and melanoma by reversing drug resistance.

Area of Science:

Nanomedicine
Biotechnology
Cancer Therapy

Background:

Lipid nanocapsules (LNCs) were initially developed for lipophilic drug delivery.
Recent advancements focus on re-designing LNCs for nucleic acid delivery to cancer cells.

Purpose of the Study:

To review the features of LNCs for nucleic acid delivery.
To summarize the encapsulation and transfection of DNA and RNA using LNCs.
To discuss the application of LNCs in anti-cancer therapies, particularly for glioma and melanoma.

Main Methods:

Review of existing literature on LNCs and nucleic acid delivery.
Analysis of studies on LNCs encapsulating DNA or RNA.
Evaluation of in vitro and in vivo transfection results.

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Published on: February 1, 2019

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Last Updated: Mar 23, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

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Published on: February 1, 2019

Main Results:

LNCs can effectively associate or encapsulate DNA and RNA.
Transfection studies demonstrate the efficacy of LNCs in delivering nucleic acids.
LNCs show potential in reversing acquired resistance in cancer cells.

Conclusions:

Lipid nanocapsules are versatile nanocarriers for nucleic acid delivery.
LNCs offer a promising strategy for anti-cancer therapies, especially for challenging cancers like glioma and melanoma.