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Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis

Gang Yao1, Ping Wang2, Xiang-Dan Luo3

  • 1Department of Neurology, The Second Hospital of Jilin University, Changchun, Jilin, China; Applied Immunology & Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna, Stockholm, Sweden.

Neuroscience Letters
|April 2, 2016
PubMed

Insights

Helicobacter pylori (H. pylori) infection is less common in multiple sclerosis (MS) patients compared to healthy individuals. This suggests H. pylori may have a protective effect against MS, particularly in Western populations.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Epidemiology

Background:

  • The relationship between Helicobacter pylori (H. pylori) infection and multiple sclerosis (MS) remains debated.
  • Existing research shows conflicting results regarding H. pylori prevalence in MS patients versus controls.

Purpose of the Study:

  • To conduct a meta-analysis to estimate the prevalence of H. pylori infection in MS patients and healthy controls.
  • To clarify the association between H. pylori infection and MS risk.

Main Methods:

  • A systematic literature search was performed on PubMed and EMBASE.
  • Nine eligible studies comprising 1553 MS patients and 1253 controls were included in the meta-analysis.

Main Results:

  • The overall prevalence of H. pylori infection was lower in MS patients (24.66%) than in controls (31.84%), with a significant inverse association (OR=0.69).
  • Subgroup analysis indicated a significantly lower prevalence in Western countries (OR=0.63) but not in Eastern countries (OR=0.79).

Conclusions:

  • H. pylori infection is negatively correlated with MS, suggesting a potential protective role, especially in Western populations.
  • Further large-scale, prospective studies are warranted to confirm if H. pylori infection is a protective factor against MS.
Keywords:
Helicobacter pyloriMeta-analysisMultiple sclerosis

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